Title of article :
Structure–activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes Original Research Article
Author/Authors :
Georgia Antonopoulou، نويسنده , , Efrosini Barbayianni، نويسنده , , Victoria Magrioti، نويسنده , , Naomi Cotton، نويسنده , , Daren Stephens، نويسنده , , Violetta Constantinou-Kokotou، نويسنده , , Edward A. Dennis، نويسنده , , George Kokotos، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA2 and GVIA iPLA2) and one human secretory phospholipase (GV sPLA2) was evaluated. We show that an amide based on (R)-γ-norleucine is a highly selective inhibitor of GV sPLA2.
Keywords :
Inhibitors , 2-Oxoamides , Amides , Phospholipase A2 , Amino acids
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
