Title of article :
Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening
Author/Authors :
Hendra Gunosewoyo، نويسنده , , Mark J. Coster، نويسنده , , Maxwell R. Bennett، نويسنده , , Michael Kassiou، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
Keywords :
P2X7 antagonists , Cytokine release , rational drug design , LL-37
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
