Title of article
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors Original Research Article
Author/Authors
Takayoshi Suzuki، نويسنده , , Keiko Imai، نويسنده , , Erika Imai، نويسنده , , Shinsuke Iida، نويسنده , , Ryuzo Ueda، نويسنده , , Hiroki Tsumoto، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
6
From page
5900
To page
5905
Abstract
A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.
Keywords
SIRT1 inhibitor , Enzyme assay , Tumor cell growth inhibition , 2-Anilinobenzamide derivative , Daudi cells , HCT116 cells
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306257
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