Title of article
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure–activity relationship studies Original Research Article
Author/Authors
Sandra Gemma، نويسنده , , Luisa Savini، نويسنده , , Maria Altarelli، نويسنده , , Pierangela Tripaldi، نويسنده , , Luisa Chiasserini، نويسنده , , Salvatore Sanna Coccone، نويسنده , , Vinod Kumar، نويسنده , , Caterina Camodeca، نويسنده , , Giuseppe Campiani، نويسنده , , Ettore Novellino، نويسنده , , Sandra Clarizio، نويسنده , , Giovanni Delogu، نويسنده , , Stefania Butini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
10
From page
6063
To page
6072
Abstract
A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 μg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
Keywords
Mycobacterium tuberculosis , Hydrazone , Quinoline
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306276
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