Title of article :
Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent Original Research Article
Author/Authors :
Hee Chun Jeong، نويسنده , , No-Joong Park، نويسنده , , Chong Hak Chae، نويسنده , , Kamil Musilek، نويسنده , , Jiri Kassa، نويسنده , , Kamil Kuca، نويسنده , , Young-Sik Jung، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
5
From page :
6213
To page :
6217
Abstract :
A series of fluorinated oxime compounds was designed and synthesized in order to probe the effect of fluorine substitution on reactivation of inhibited acetylcholinesterase (AChE) by organophosphorus agents. Permeability measurements, using the Parallel Artificial Membrane Permeation Assays (PAMPA) method, were employed to experimentally demonstrate that membrane permeabilities of the series of oximes increase in proportional to the increase in the number of fluorine atoms. Among the compounds explored in this study, the mono-fluorinated carbamoyl aldoxime 4b was the most potent reactivator for paraoxon-inhibited red blood cell (RBC) AChE.
Keywords :
Organophosphorus agents , Fluorinated pyridinium oxime , Acetylcholinesterase , Oxime reactivators
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2009
Journal title :
Bioorganic and Medicinal Chemistry
Record number :
1306301
Link To Document :
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