Title of article
Synthesis and biological evaluation of 3,4-diaryl-5-aminoisoxazole derivatives Original Research Article
Author/Authors
Tao Liu، نويسنده , , Xiaowu Dong، نويسنده , , Na Xue، نويسنده , , Rui Wu، نويسنده , , Qiaojun He، نويسنده , , Bo Yang، نويسنده , , Yongzhou Hu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
6279
To page
6285
Abstract
A series of cis-restricted 3,4-diaryl-5-aminoisoxazoles have been synthesized and evaluated for their biological activities. Among them, compound 11a and 13a displayed potent cytotoxic activities in vitro against five human cancer cell lines with IC50 values in the low micromolar range and two compounds inhibited tubulin polymerization with IC50 value of 1.8, and 2.1 μM, respectively, similar to that of CA-4. Compound 13a could arrest at the G2/M phase of the cell cycle at the concentration of 0.1 and 1.0 μM and induce apoptosis at 0.1–1.0 μM.
Keywords
3 , 4-Diaryl-5-aminoisoxazole , Cytotoxic activities , Tubulin polymerization inhibition
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306318
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