Title of article
Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes Original Research Article
Author/Authors
Daniel Obando، نويسنده , , Namfon Pantarat، نويسنده , , Rosemary Handke، نويسنده , , Yasuko Koda، نويسنده , , Fred Widmer، نويسنده , , Julianne T. Djordjevic، نويسنده , , David H. Ellis، نويسنده , , Tania C. Sorrell، نويسنده , , Katrina A. Jolliffe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
11
From page
6329
To page
6339
Abstract
A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.
Keywords
Bispyridinium , Antifungal activity , Fungal phospholipase B , Haemolytic activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306325
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