Title of article
2-Benzoylpyridine-N(4)-tolyl thiosemicarbazones and their palladium(II) complexes: Cytotoxicity against leukemia cells Original Research Article
Author/Authors
Karina S.O. Ferraz، نويسنده , , Lucas Ferandes، نويسنده , , Diego Carrilho، نويسنده , , Mauro C.X. Pinto، نويسنده , , Maria de F?tima Leite، نويسنده , , Elaine M. Souza–Fagundes، نويسنده , , Nivaldo L. Speziali، نويسنده , , Isolda C. Mendes، نويسنده , , Heloisa Beraldo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
7138
To page
7144
Abstract
The palladium(II) complexes [Pd(2Bz4oT)Cl], [Pd(2Bz4mT)Cl], and [Pd(2Bz4pT)Cl] were prepared with N(4)-ortho- (H2Bz4oT) N(4)-meta- (H2Bz4mT) and N(4)-para- (H2Bz4pT) tolyl-thiosemicarbazones derived from 2-benzoylpyridine. The free thiosemicarbazones proved to be highly cytotoxic against Jurkat, HL60 and the resistant HL60.Bcl-XL leukemia cell lines at nanomolar concentrations, but were much less cytotoxic to HepG2 human hepatoma cells. Upon coordination to palladium(II) the cytotoxic activity against all studied cell lines decreases. However, the high cytotoxicity of the free thiosemicarbazones against leukemia, together with their hepatotoxic profile similar to that of cisplatin suggest that N(4)-tolyl thiosemicarbazones have potential as chemotherapeutic drug candidates.
Keywords
Palladium(II) complexes , Thiosemicarbazones , Leukemia
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306427
Link To Document