Author/Authors :
Anil Kanaujia، نويسنده , , Rajeev Duggar، نويسنده , , Steve Thomas Pannakal، نويسنده , , Satyapal Singh Yadav، نويسنده , , Chandra Kant Katiyar، نويسنده , , Vinay Bansal، نويسنده , , S. Anand، نويسنده , , S. Sujatha، نويسنده , , B.S. Lakshmi، نويسنده ,
Abstract :
Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10 ng/ml and 100 ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.
