Title of article
Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-l-aspartic acid as inhibitors of aminopeptidase N/CD13 Original Research Article
Author/Authors
Yingzi Liu، نويسنده , , Luqing Shang، نويسنده , , Ku-Hao Fang، نويسنده , , and Huawei Zhu، نويسنده , , Jiajia Mu، نويسنده , , Qiang Wang، نويسنده , , Xuejian Wang، نويسنده , , Yumei Yuan، نويسنده , , Wenfang Xu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
7398
To page
7404
Abstract
A series of novel derivatives of N-cinnamoyl-l-aspartic acid were designed, synthesized, and assayed for their inhibitory activities against aminopeptidase N. The preliminary biological assay showed that compound 8c has the most potent inhibitory activity against APN with an IC50 of 11.1 ± 0.9 μM, this could be used as the lead compound in future research on anticancer agents.
Keywords
N-Cinnamoyl-l-aspartic acid derivatives , Aminopeptidase N inhibitors , Synthesis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306477
Link To Document