Title of article :
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers Original Research Article
Author/Authors :
Elisabetta Martini، نويسنده , , Alberto Salvicchi، نويسنده , , Carla Ghelardini، نويسنده , , Dina Manetti، نويسنده , , Silvia Dei، نويسنده , , Luca Guandalini، نويسنده , , Cecilia Martelli، نويسنده , , Michele Melchiorre، نويسنده , , Cristina Cellai، نويسنده , , Serena Scapecchi، نويسنده , , Elisabetta Teodori، نويسنده , , Maria Novella Romanelli، نويسنده ,
Abstract :
A series of amides and sulfonamides, structurally related to DM235 (sunifiram) and MN19 (sapunifiram), derived by ring expansion or contraction, or by inversion of the exocyclic amide function, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, and with a potency similar to the parent compounds.
Keywords :
Cognition-enhancers , Sunifiram , Sapunifiram , Mouse passive-avoidance test
