Author/Authors :
Khalid Mohammed Khan، نويسنده , , Momin Khan، نويسنده , , Muhammad Ali، نويسنده , , Muhammad Taha، نويسنده , , Saima Rasheed، نويسنده , , Shahnaz Perveen، نويسنده , , M. Iqbal Choudhary، نويسنده ,
Abstract :
Bis-Schiff bases 1–27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC50 = 243.95 ± 4.59 μM), 20 (IC50 = 257.61 ± 5.63 μM), and 7 (IC50 = 291.14 ± 2.53 μM) showed an excellent antiglycation activity better than the standard (rutin, IC50 = 294.46 ± 1.50 μM). This study has identified a series of potential molecules as antiglycation agents. A structure–activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.
