Author/Authors :
Chung Hin Chui، نويسنده , , Raymond Siu Ming Wong، نويسنده , , University of Perugia
Roberto Gambari، نويسنده , , Gregory Yin Ming Cheng، نويسنده , , Marcus Chun-wah Yuen، نويسنده , , Kit-Wah Chan، نويسنده , , See-Wai Tong، نويسنده , , Fung Yi Lau، نويسنده , , Paul Bo San Lai، نويسنده , , Kim-Hung Lam، نويسنده , , Cheuk-Lam Ho، نويسنده , , Chi-Wai Kan، نويسنده , , Kelvin Sze-Yin Leung، نويسنده , , Wai Yeung Wong، نويسنده ,
Abstract :
A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure–activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.
Keywords :
alkynes , Gold(I) complexes , Fluorenes derivatives , Human carcinoma cells , Nude mice model , Reactive oxygen species
