Title of article
ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors Original Research Article
Author/Authors
Baihua Xu، نويسنده , , Yan Feng، نويسنده , , Binhua Lv، نويسنده , , Yu-ge XU، نويسنده , , Lili Zhang، نويسنده , , Jiyan Du، نويسنده , , Shin-Kun Peng، نويسنده , , Min Xu، نويسنده , , Jiajia Dong، نويسنده , , Wenbin Zhang، نويسنده , , Ting Zhang، نويسنده , , Liangcheng Zhu، نويسنده , , Haifeng Ding، نويسنده , , Zelin Sheng، نويسنده , , Ajith Welihinda، نويسنده , , Brian Seed، نويسنده , , Yuanwei Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
11
From page
4422
To page
4432
Abstract
A series of 2-substituted C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Introduction of an appropriate ortho substituent at the proximal phenyl ring adjacent to the glycosidic bond was found to improve SGLT2 inhibitory activity and dramatically increase selectivity for hSGLT2 over hSGLT1. Selected compounds were investigated for in vivo efficacy.
Keywords
Diabetes , SGLT , Urinary glucose , ortho-Substituted C-aryl glucosides , Blood glucose , Sodium-dependent glucose co-transporter
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306581
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