Title of article
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II Original Research Article
Author/Authors
William J. Moore، نويسنده , , Jeffrey C. Kern، نويسنده , , Ramesh Bhat، نويسنده , , Peter V.N. Bodine، نويسنده , , Shoichi Fukyama، نويسنده , , Girija Krishnamurthy، نويسنده , , Ronald L. Magolda، نويسنده , , Keith Pitts، نويسنده , , Barb Stauffer، نويسنده , , Eugene J. Trybulski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
12
From page
190
To page
201
Abstract
Piperidinyl diphenylsulfonyl sulfonamides are a novel class of molecules that have inhibitory binding affinity for sFRP-1. As a secreted protein sFRP-1 inhibits the function of the secreted Wnt glycoprotein. Therefore, as inhibitors of sFRP-1 these small molecules facilitate the Wnt/β-catenin canonical signaling pathway. Details of the structure–activity relationships and biological activity of this structural class of compounds will be discussed.
Keywords
Secreted-frizzled related protein-1 (sFRP-1) , Wnt pathway , Osteoblasts , Osteoporosis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306656
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