Author/Authors :
Yu Luo، نويسنده , , Jia-Ping Yao، نويسنده , , Li Yang، نويسنده , , Chun-Lan Feng، نويسنده , , Wei Tang، نويسنده , , Gui-Feng Wang، نويسنده , , Jian-Pin Zuo، نويسنده , , Wei Lu، نويسنده ,
Abstract :
A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50 <0.41 μM and SI >81.2, was the most promising compound and selected as the benchmark compound for further optimization.
