Title of article :
Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amide Original Research Article
Author/Authors :
Yushi Chi، نويسنده , , Huibin Zhang، نويسنده , , Wenlong Huang، نويسنده , , Jinpei Zhou، نويسنده , , Yinghong Zhou، نويسنده , , Hai Qian، نويسنده , , Shuaijian Ni، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The insulinotropic hormone glucagon-like peptide-1 (GLP-1) is rapidly inactivated in the body. In order to improve its stability, we replaced the enzymatic hydrolyzation position Ala8with Gly and replaced Ala30 with Cys firstly. Then the modified peptide was further PEGylated at thiol group of Cys30. Biological activity studies showed that the resulting mPEG-MAL-Gly8-Cys30-GLP-1(7–36)-NH2 exhibited long-lasting effect while maintaining moderate glucose-lowering activity.
Keywords :
GLP-1 , Microwave , Pegylation , DPP IV , Glucose-lowering effect
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
