Title of article
Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma Original Research Article
Author/Authors
Nicolas Desbois، نويسنده , , Maryline Gardette، نويسنده , , Janine Papon، نويسنده , , Pierre Labarre، نويسنده , , Aurélie Maisonial، نويسنده , , Philippe Auzeloux، نويسنده , , Claire Lartigue، نويسنده , , Bernadette Bouchon-Meunier، نويسنده , , Eric Debiton، نويسنده , , Yves Blache، نويسنده , , Olivier Chavignon، نويسنده , , Jean-Claude Teulade، نويسنده , , Jean Maublant، نويسنده , , Jean-Claude Madelmont، نويسنده , , Nicole Moins، نويسنده , , Jean-Michel Chezal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
20
From page
7671
To page
7690
Abstract
Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [125I]NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumour-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumour concentrations together with an in vivo kinetic profile favourable to application in targeted radionuclide therapy.
Keywords
Melanoma treatment , Targeted therapy , Acridine , Radionuclide therapy
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306822
Link To Document