Title of article
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers Original Research Article
Author/Authors
Yangming Zhang، نويسنده , , Yu Ding، نويسنده , , Wei Tang، نويسنده , , Wei Luo، نويسنده , , Min Gu، نويسنده , , Wei Lu، نويسنده , , Jie Tang، نويسنده , , Jian-Ping Zuo، نويسنده , , Fa-Jun Nan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
9212
To page
9216
Abstract
DZ2002 and its related stereoisomers were efficiently synthesized. The optical data of (R)- and (S)-DZ2002 were disclosed here for the first time. Their inhibitory potency was evaluated on SAHase and MLR assay in the mean time. In accordance with respective inhibitory potency of SAHase, the immunosuppressive potency order was demonstrated as (S)-DZ2002 > (Rac)-DZ2002 > (R)-DZ2002 > (Keto)-DZ2002. These results indicate (S)-configuration of 2-chiral center in DZ2002 is important for binding with SAHase.
Keywords
Synthesis , Stereoisomers , Immunosuppressive potency , S-Adenosyl-l-homocysteine hydrolase , DZ2002
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306946
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