Title of article
Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues Original Research Article
Author/Authors
Marcus B?ck، نويسنده , , Jonas Nyhlén، نويسنده , , Ingemar Kvarnstr?m، نويسنده , , Sara Appelgren، نويسنده , , Neera Borkakoti، نويسنده , , Katarina Jansson، نويسنده , , Jimmy Lindberg، نويسنده , , Susanne Nystr?m، نويسنده , , Anders Hallberg، نويسنده , , Asa Rosenquist، نويسنده , , Bertil Samuelsson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
16
From page
9471
To page
9486
Abstract
Several BACE-1 inhibitors with low nanomolar level activities, encompassing a statine-based core structure with phenyloxymethyl- and benzyloxymethyl residues in the P1 position, are presented. The novel P1 modification introduced to allow the facile exploration of the S1 binding pocket of BACE-1, delivered highly promising inhibitors.
Keywords
Alzheimer’s disease , BACE-1 inhibitors , P1 modifications , peptidomimetics
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306976
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