Author/Authors :
Adriana S. Brito، نويسنده , , Dayse S. Arimatéia، نويسنده , , Lucilla R. Souza، نويسنده , , Marcelo A. Lima، نويسنده , , Vanessa O. Santos، نويسنده , , Valqu?ria P. Medeiros، نويسنده , , Paula A. Ferreira، نويسنده , , Rodrigo A. Silva، نويسنده , , Carmen V. Ferreira، نويسنده , , Giselle Z. Justo، نويسنده , , Edda L. Leite، نويسنده , , Giulianna P.V. Andrade، نويسنده , , Fernanda W. Oliveira، نويسنده , , Helena B. Nader، نويسنده , , Suely F. Chavante، نويسنده ,
Abstract :
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.
Keywords :
invertebrate , Anticoagulant activity , Litopenaeus vannamei , Heparin , Glycosaminoglycans , Matrix metalloproteinases , Anti-inflammatory activity , Hemorrhagic activity , Crustacean heparin-like compound
