Author/Authors :
Daniela Rossi، نويسنده , , Mariangela Urbano، نويسنده , , Alice Pedrali، نويسنده , , Massimo Serra، نويسنده , , Daniele Zampieri، نويسنده , , Maria Grazia Mamolo، نويسنده , , Christian Laggner، نويسنده , , Caterina Zanette، نويسنده , , Chiara Florio، نويسنده , , Dirk Schepmann، نويسنده , , Bernard Wuensch، نويسنده , , Ornella Azzolina، نويسنده , , Simona Collina، نويسنده ,
Abstract :
In order to investigate the molecular features involved in sigma receptors (σ-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards σ1- and σ2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at μ-opioid, δ-opioid and κ-opioid receptors. Biological results are herein presented and discussed.
Keywords :
Sigma ligands , Arylalkylaminoalcohols , Arylalkenylamines , Arylalkylamines , Radioligand binding assays , Pd(0) EnCat™ 30NP(en)
