Title of article :
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs Original Research Article
Author/Authors :
Congde Huo، نويسنده , , Huanjie Yang، نويسنده , , Qiuzhi Cindy Cui، نويسنده , , Q. Ping Dou، نويسنده , , Tak Hang Chan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT.
Keywords :
Endo-M , Transglycosylation , Chemo-enzymatic synthesis , Insulin , Modification of protein
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
