Author/Authors :
Muthukumar Karuppasamy، نويسنده , , Manojkumar Mahapatra، نويسنده , , Samiye Yabanoglu، نويسنده , , Gülberk Ucar، نويسنده , , Barij Nayan Sinha، نويسنده , , Arijit Basu، نويسنده , , Nibha Mishra، نويسنده , , Ashoke Sharon، نويسنده , , Umasankar Kulandaivelu، نويسنده , , Venkatesan Jayaprakash، نويسنده ,
Abstract :
3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 103–105. The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (Ki) values obtained by molecular docking studies were in congruence with their experimental (Ki) values.
