Title of article
Synthesis, in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells Original Research Article
Author/Authors
Pijus Saha، نويسنده , , Claudia H?dl، نويسنده , , Wolfgang S.L. Strauss، نويسنده , , Rudolf Steiner، نويسنده , , Walter Goessler، نويسنده , , Olaf Kunert، نويسنده , , Alexander Leitner، نويسنده , , Ernst Haslinger، نويسنده , , H. Wolfgang Schramm، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
8
From page
1891
To page
1898
Abstract
Novel gadolinium-based mifepristone conjugates were synthesised using various synthetic routes. Moderate antiprogestagenic activity of the new conjugates was observed in human breast cancer cells (T47-D cells) using AP (alkaline phosphatase) assay. The amount of incorporated Gd determined by inductively coupled plasma mass spectroscopy (ICPMS) indicates the number of binding sites per cell. These conjugates might be important compounds to develop receptor-targeted MRI contrast agents as well as other anti-breast cancer therapeutics.
Keywords
Gadolinium-based mifepristone conjugates , Proton relaxation , Antiprogestagenic activity , T47-D human breast cancer cells , Progesterone binding sites
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307189
Link To Document