Title of article
Enhancement of antiproliferative activity by molecular simplification of catalpol Original Research Article
Author/Authors
Celina Garc?a، نويسنده , , Leticia G. Le?n، نويسنده , , Carlos R. Pungitore، نويسنده , , Carla R?os-Luci، نويسنده , , Antonio H. Daranas، نويسنده , , Juan C. Montero، نويسنده , , Atanasio Pandiella، نويسنده , , Carlos E. Tonn، نويسنده , , Victor S. Martin، نويسنده , , José M. Padr?n، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
9
From page
2515
To page
2523
Abstract
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed α-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38–1.86 μM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining.
Keywords
cell cycle , Structure elucidation , Molecular simplification , Catalpol , Antitumor agents
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307255
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