Author/Authors :
John B. Bremner، نويسنده , , Paul A. Keller، نويسنده , , Stephen G. Pyne، نويسنده , , Timothy P. Boyle، نويسنده , , Zinka Brkic، نويسنده , , Dorothy M. David، نويسنده , , Mark Robertson، نويسنده , , Kittiya Somphol، نويسنده , , Dean Baylis، نويسنده , , Jonathan A. Coates، نويسنده , , John Deadman، نويسنده , , Darshini Jeevarajah، نويسنده , , David I. Rhodes، نويسنده ,
Abstract :
An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9–3.9 μg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 μg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2 μg/mL against vancomycin-resistant strains of enterococci (VRE).
Keywords :
Tripeptoids , Binaphthyl , Cationic , Antibacterial
