Author/Authors :
Anna Mrozek-Wilczkiewicz، نويسنده , , Danuta S. Kalinowski، نويسنده , , Robert Musiol، نويسنده , , Jacek Finster، نويسنده , , Agnieszka Szurko، نويسنده , , Katarzyna Serafin، نويسنده , , Magdalena Knas، نويسنده , , Sishir K. Kamalapuram، نويسنده , , Zaklina Kovacevic، نويسنده , , Josef Jampilek، نويسنده , , Alicja Ratuszna، نويسنده , , Joanna Rzeszowska-Wolny، نويسنده , , Des R. Richardson، نويسنده , , Jaroslaw Polanski، نويسنده ,
Abstract :
A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin.
