Title of article
New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents Original Research Article
Author/Authors
Saioa Ancizu، نويسنده , , Elsa Moreno، نويسنده , , Beatriz Solano، نويسنده , , Raquel Villar، نويسنده , , Asunci?n Burguete، نويسنده , , Enrique Torres Vaamonde، نويسنده , , Silvia Pérez-Silanes، نويسنده , , Ignacio Aldana، نويسنده , , Antonio Monge، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
7
From page
2713
To page
2719
Abstract
Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).
Keywords
4-di-N-oxide derivatives , Quinoxaline 1 , Mycobacterium tuberculosis (M.Tb.) , Rifampin , Anti-tuberculosis agents
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307276
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