Title of article
Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster Original Research Article
Author/Authors
Tadashi Tatsumi، نويسنده , , Chiyuki Awahara، نويسنده , , Hiromi Naka، نويسنده , , Saburo Aimoto and Yoshifumi Nishimura، نويسنده , , Hiroyuki Konno، نويسنده , , Kazuto Nosaka، نويسنده , , Kenichi Akaji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
8
From page
2720
To page
2727
Abstract
Effects of retro-inverso (RI) modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster backbone were clarified. Construction of the isoster backbone was achieved by a stereoselective aldol reaction. Four diastereomers with different configurations at the isoster hydroxyl site and the scissile site substituent were synthesized. Inhibitory activities of the new inhibitors suggest that partially modified RI inhibitors would interact with HTLV-1 protease in the same manner as the parent hydroxyethylamine inhibitor.
Keywords
HTLV-1 protease , Inhibitor , Hydroxyethylamine isoster , Retro inverso
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307277
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