Author/Authors :
Aldo Andreani، نويسنده , , Silvia Burnelli، نويسنده , , Massimiliano Granaiola، نويسنده , , Alberto Leoni، نويسنده , , Alessandra Locatelli، نويسنده , , Rita Morigi، نويسنده , , Mirella Rambaldi، نويسنده , , Lucilla Varoli، نويسنده , , Laura Landi، نويسنده , , Cecilia Prata*، نويسنده , , Francesco Vieceli Dalla Sega، نويسنده , , Cristiana Caliceti، نويسنده , , Robert H. Shoemaker، نويسنده ,
Abstract :
This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure–activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction.
Keywords :
Pyridine , Hollow fiber assay , Antitumor , COMPARE , NQO1 , Indole
