Controlled release of drug from cyclodextrin-intercalated layered double hydroxide Original Research Article

The intercalation of sulfobutyl ether β-cyclodextrin (SBE7-β-CD) into Mg–Al-layered double hydroxide (abbreviated as LDH) known as hydrotalcite was examined aiming for the controlled release of drugs. Complete intercalation of SBE7-β-CD was attained using LDH(NO3) with Mg/Al ratio of 2. The intercalation compound showed the interlayer distance of 2.15 nm. Above 1 mM of SBE7-β-CD aqueous solution, the intercalation compound with different uptake amount of SBE7-β-CD was obtained as a single phase. The inclusion of prazosin could be attained by two methods, that is, the inclusion by SBE7-β-CD-intercalated LDH and the intercalation of prazosin-included SBE7-β-CD in LDH(NO3). And the sustained release of prazosin was attained successfully by regulating the uptake of SBE7-β-CD.