Author/Authors :
Soltanian، Ali Reza نويسنده Department of Biostatistics and Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran , , Faghihzadeh، S نويسنده Dept. of Biostatistics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Mehdibarzi ، D نويسنده Dept. of Orthopaedics, Faculty of Medical Sciences, Shahed University, Tehran, Iran , , Gerami، A نويسنده Dept. of Mathematical Statistics, School of Mathematics, Statistics and Computer Sciences, Tehran Uni versity, Iran , , Nasery، M نويسنده Dept. of Pharmacology, Faculty of Medical Sciences, Shahed University, Tehran, Iran , , Cheng، J نويسنده Dept. of Biostatistics &Epidemiology, University of Florida, Gainesville, U.S.A ,
Abstract :
Background: Osteoarthritis is the most prevalent chronic non-infective joint arthritis. In the present study, the effect of new herbal pomade (Marhame-Mafasel) on knee osteoarthritis was investigated in a randomized trial. The objective of this study was to assess efficacy of Marhame- Mafasel pomade, which was consisted of several medic herbs like Arnebia euchroma and Martricaria chamomilla in pri mary osteoarthritis of the knee with non-compliance.
Methods: The 2?2 crossover trial enrolled 42 osteoarthritis patients (Marhame-Mafasel versus pla-cebo) in 2006. The instrument of data collection was Western Ontario and McMaster Universities (WOMAC) LK3.1 standard questionnaires. We used conditional estimation to adjust non-compliance ef fect.
Results: The participants in each group were 21 patients. About 30 (71.4%) were female. The partici-pants were between 40-76 years old. Positive analgesic effect of herbal pomade “Marhame-Mafasel” on knee osteoarthritis severity was considerable (P < 0.01). After adjusting results to compliance level, the estimators were sharper than crude results.
Conclusion: Herbal joint pomade "Marhame-Mafasel" has significant positive analgesic effect on pri mary knee osteoarthritis.
