Author/Authors :
Ramezani، Mohsen نويسنده Department of Endodontics, Dental School, Mazandaran University of Medical Sciences, Sari, Iran , , Hamidi، Mahmoud Reza نويسنده Department of Endodontics, Dental School, Babol University of Medical Sciences, Babol, Iran , , Moghaddamnia، Ali Akbar نويسنده Department of Physiology and Pharmacology, Babol University of Medical Science, Babol, Iran , , Ramezani، Nahid نويسنده Department of Pedodontics, Children And Adolescent Health Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan, Iran , , Zarenejad، Nafiseh نويسنده Department of Restorative Dentistry, Dental School, Babol University of e Medical Sciences, Babol, Iran ,
Abstract :
Introduction: Post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. The purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of Zingiber Officinale, Zintoma, and Ibuprofen on post endodontic pain of molars with irreversible pulpitis. Materials and Methods: The post endodontic pain of 72 enrolled patients suffering from irreversible pulpitis was assessed after prophylactic use of 400 mg Ibuprofen, 2 gr Zintoma and placebo. Using the Heft-Parker Visual Analogue Scale, the patients recorded their perceived pain before taking the medicament (baseline), immediately after and also at 4, 8, 12, 24, 48, and 72 h post one-visit endodontic treatment. The statistical analysis was done using Kruskal-Wallis, Mann-Whitney, and Freedman tests (P < 0.05). Results: At all times, there was significant difference between the Ibuprofen and Zintoma (P < 0.05) and also between the Ibuprofen and placebo (P < 0.05). However, there was no significant difference between Zintoma and the placebo in any of time intervals (P > 0.05). No side effects were observed. Conclusion: The obtained results of the trial revealed that prophylactic use of 2 gr Zintoma is not an effective pain relieving agent.
