Author/Authors :
Yaghoobi، Nahid نويسنده Associate Professor, Department of Nuclear Medicine and Molecular Imaging, Rajaie Cardiovascular, Medical and Research Center , , Rastgou ، Feridoon نويسنده (Correspondent author) Assistant professor , Department of Nuclear Medicine and Molecular Imaging. Rajaei Cardiovascular, Medical and Research Center. Iran University of Medical Sciences, Tehran, Iran. ,
Abstract :
Background. Myocardial perfusion imaging (MPI) with gated single-photon emission computed tomography (SPECT) has been introduced as a feasible tool for the evaluation of the left ventricular diastolic function. Diastolic dysfunction is a relatively common disorder, to which several factors such as obesity have been shown to contribute. However, despite high prevalence of obesity in the population, the impact of obesity on diastolic parameters derived from gated SPECT MPI is not well investigated.
Methods. A total of 219 consecutive patients with no history of cardiac disease and with a low likelihood ratio for coronary artery disease who were referred to the Nuclear Medicine Department to undergo MPI for any reason were enrolled to the study. Post-stress gated SPECT data were used for the calculation of diastolic function parameters, including peak filling rate (PFR) and time to peak filling rate (TTPF). Correlation and relationship of these parameters with the body mass index (BMI) of the patients, which had been measured before imaging, were analyzed.
Results. The BMI showed no significant correlation with TTPF, PFR, PFR2, and mean filling rate at one third of diastole (MFR/3) derived by gated SPECT MPI. In addition, no statistically significant difference was found for the diastolic parameters between the BMI subgroups in the female, male, and the total patients. PFR, PFR2, and MFR/3, however, were significantly lower in the males and elderly patients.
Conclusion. As an indicator of obesity, the BMI disclosed no significant correlation with the left ventricular diastolic parameters in the patients with a low likelihood of coronary artery disease, which was in contrast with the other similar studies by echocardiography on patients with positive CAD risk factors. It, therefore, may imply that the impact of obesity on the left ventricular diastolic function could be accentuated by the other CAD risk factors and that it does not represent a unifactorial correlation, which warrants further dedicated studies
