Synthesis, characterization and in vitro antitumor activity of diorganometallo complexes γ-Keggin anions

Diorganometallo-substituted γ-Keggin heteropolytungstates γ-[(RSn)2SiW10O38]6−[R=MeOCOCH2CH2, MeOCOCH(Me)CH2,NCCH2CH2], γ-[(CpTi)2SiW10O38]6− and γ-[(CpZr)2SiW10O38]6− have been prepared from the divacant polyanion γ-SiW10O368− and their structures have been determined by NMR spectroscopy. The 183W NMR spectra of complexes show three peaks, indicating that these anions have the anticipated γ-Keggin structure with C2V symmetry. The title complexes exhibit antitumor activity in vitro.