Title of article :
DNA binding behaviors and nuclease activities of novel mixed-ligand ruthenium(II) complexes
Author/Authors :
Naho Iizuka، نويسنده , , Shoichi Motoki، نويسنده , , Misaki Nakai، نويسنده , , Yasuo Nakabayashi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
Two types of ruthenium(II) complexes cis-[Ru(bpy)2ClL]+ and cis-[Ru(bpy)2L2]2 + (L = 1,6-diaminohexane (1,6-dahx), 1-aminohexane (1-ahx)) were synthesized, and the interactions of these complexes with DNA were investigated. Importantly, cis-[Ru(bpy)2(1,6-dahx)2]2 + possessed hydrogen-bonding to DNA, preferentially binds at adenine and/or thymine residues, and exhibits more efficient nuclease activity.
Keywords :
Mixed-ligand ruthenium(II) complex , Hydrogen-bonding , DNA sequence-specific recognition , Nuclease activity , Noncovalent DNA-binding
Journal title :
Inorganic Chemistry Communications
Journal title :
Inorganic Chemistry Communications
