Structural characterization and SOD activity of copper–oxaprozinate

SOD activity of the diaryl substituted heterocyclic COX-2 inhibitor, viz. oxaprozin (2), is synergistically enhanced upon copper conjugation compared to analogous copper compounds of established COX-1 inhibitors like aspirin (1) and ibuprofen (3). A “paddle-wheel” structure is reported for the dimeric copper complex of oxaprozin.