Title of article
Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes
Author/Authors
Santiago G?mez-Ruiz، نويسنده , , Goran N. Kalu?erovi?، نويسنده , , Dorian Polo-Cer?n، نويسنده , , Sanjiv Prashar، نويسنده , , Mariano Fajardo، نويسنده , , ?eljko ?i?ak، نويسنده , , Zorica D. Jurani?، نويسنده , , Tibor J. Sabo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
748
To page
752
Abstract
The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me(CH2double bond; length as m-dashCH)Si(η5-5Me4) (η5-C5H4)}Cl2] (1), [Ti{Me(H)Si(η5-C5Me4)2}Cl2] (2), [Ti{Me{(CH2double bond; length as m-dashCH)Me2SiCH2CH2}Si(η5-C5Me4)(η5-C5H4)}Cl2] (3) and [Ti{Me2Si(η5-C5Me4)(η5-C5H3(CMe2(CH2CH2CHdouble bond; length as m-dashCH2)))}Cl2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field.
Keywords
Adenocarcinoma HeLa , Human myelogenous leukemia K562 , ansa-Titanocene compounds , Antitumoural activity , Human malignant melanoma Fem-x
Journal title
Inorganic Chemistry Communications
Serial Year
2007
Journal title
Inorganic Chemistry Communications
Record number
1317412
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