Author/Authors :
Florian P. Pruchnik، نويسنده , , Piotr Jakimowicz، نويسنده , , Zbigniew Ciunik، نويسنده , , Jolanta Zakrzewska-Czerwi?ska، نويسنده , , Adam Opolski، نويسنده , , Joanna Wietrzyk، نويسنده , , El?bieta Wojdat، نويسنده ,
Abstract :
Synthesis and properties of rhodium complexes with nitrogen ligands [RhCl2(Hpz)4][RhCl4(Hpz)2] (1), [RhCl3(tpy)] (2), [RhCl3(tpta)]·H2O (3) and [Rh(tpy)2(Him)]Cl3·3H2O (4), have been described. X-ray structures of complexes 1–3 have been determined. IR, UV–Vis and 1H NMR spectra of the complexes have been discussed. Cytostatic activity of the complexes against HCV29T tumor cells increases in the series: 1<3<2<4. The cytostatic activity of complex 4 is greater than that of cisplatin. Interaction of the complexes with DNA has been investigated.
