Porphyrin platinum conjugates – new aims

Forty porphyrin platinum conjugates were synthesized, which exhibited a photodynamic effect due to the porphyrin system and a cytostatic effect due to the platinum fragment present in the same molecule. The porphyrin ligands for the platinum complexes were synthesized starting from hematoporphyrin and deuteroporphyrin. The platinum complexes are of the (diamine)PtCl2, (diamine)Pt(phthalato), (NH3)2Pt(dicarboxylato) and (diamine)Pt(dicarboxylato) type. Their antitumor activity was tested with the MDA-MB-231 mammary carcinoma cell line with and without irradiation.