Author/Authors :
Tsotakos، نويسنده , , T. and Tsoukalas، نويسنده , , C. and Patsis، نويسنده , , G. and Panagiotopoulou، نويسنده , , A. and Nikoli?، نويسنده , , N. and Jankovi?، نويسنده , , D. and Djoki?، نويسنده , , D. and Raptopoulou، نويسنده , , C.P. and Terzis، نويسنده , , A. and Papagiannopoulou، نويسنده , , D. and Pelecanou، نويسنده , , M. P. Papadopoulos، نويسنده , , M. and Pirmettis، نويسنده , , I.، نويسنده ,
Abstract :
Two rhenium(I) tricarbonyl complexes with the tridentate monoanionic NSO ligands, 4-(benzimidazol-2-yl)-3-thiabutanoic acid (complex 3) and [1-(11-carboxyundecanyl)-4-(benzimidazol-2-yl)]-3-thiabutanoic acid (complex 4) were synthesized and characterized by spectroscopic methods and elemental analysis. X-ray crystallographic analysis of complex 3 revealed a distorted octahedral geometry around rhenium defined by the three facially bound CO groups and the NSO donor atom set of the tridentate ligand. The analogous technetium-99m complexes (complexes 5 and 6) were also prepared quantitatively by reaction of the NSO ligands with the fac-[99mTc(H2O)3(CO)3]+ synthon and their identity was established by chromatographic comparison to their rhenium congeners. Biodistribution in mice of complex 6 bearing the fatty acid chain showed significant heart uptake (6.26 ± 0.79% ID/g p.i.) at 1 min accompanied, however, with a heart:blood ratio below 1.
Keywords :
fatty acid , rhenium , Tricarbonyl , Technetium-99m
