Title of article :
Histidine derivatives as tridentate chelators for the fac-[MI(CO)3] (Re, 99mTc, 188Re) core: Synthesis, structural characterization, radiochemistry and stability
Author/Authors :
Papagiannopoulou، نويسنده , , Dionysia and Tsoukalas، نويسنده , , Charalambos and Makris، نويسنده , , George and Raptopoulou، نويسنده , , Catherine P. and Psycharis، نويسنده , , Vassilis and Leondiadis، نويسنده , , Leondios and Gniazdowska، نويسنده , , Ewa and Ko?mi?ski، نويسنده , , Przemyslaw and Fuks، نويسنده , , Leon and Pelecanou، نويسنده , , Maria and Pirmettis، نويسنده , , Ioann، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
5
From page :
333
To page :
337
Abstract :
The development of new rhenium(I)- and technetium(I)–tricarbonyl complexes can lead to potentially useful radiopharmaceuticals. In this work, the synthesis of the neutral rhenium complex fac-[Re(NSO)(CO)3], Re-1, where NSO is the tridentate chelating agent 3-(1H-imidazol-4-yl)-2-(p-methoxy-benzylthio)propionic acid 1 was effected via reaction with (NEt4)2[ReBr3(CO)3] in the presence of NaHCO3. Complex Re-1 crystallized from methanol/water and its structure was established by IR, 1H and 13C NMR spectroscopies, ESI-MS analysis and X-ray crystallography. When the reaction took place in the absence of base, HPLC analysis revealed the presence of a second product (yield 7%) that was assigned by NMR and ESI analysis to be complex fac-[Re(NS)(CO)3Br] Re-2. At the tracer level, the analogous complexes fac-[99mTc(NSO)(CO)3], 99mTc-1 and fac-[188Re(NSO)(CO)3], 188Re-1, were synthesized and their radiochemical stability in physiological conditions was determined. Both tracer complexes 99mTc-1 and 188Re-1 are stable in solution as well as in the presence of strongly coordinating agents like histidine or cysteine.
Keywords :
rhenium , Technetium , Histidine derivatives , Tricarbonyl complexes
Journal title :
INORGANICA CHIMICA ACTA
Serial Year :
2011
Journal title :
INORGANICA CHIMICA ACTA
Record number :
1330159
Link To Document :
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