Spectroscopic, kinetic and cytotoxic in vitro study of hexafluoroglutarate platinum(II) complex with 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

Reaction of cis-[PtI2(dmtp)2] (where dmtp – 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) with silver hexafluoroglutarate [Ag2(C5F6O4)] yielded new complex [Pt(C5F6O4)(dmtp)2]·2H2O. The platinum(II) complex has been characterized by 1H, 19F NMR and IR. In additional, kinetics of its hydrolysis and antiproliferative activity in vitro against three cell lines (A549 human non small cell lung carcinoma; A375.S2 human melanoma and mouse B16 melanoma tumors) has been studied.