Title of article
Synthesis and in vitro anticancer activity of ferrocenyl-aminoquinoline-carboxamide conjugates
Author/Authors
Xiomara and Esparza-Ruiz، نويسنده , , Adriana and Herrmann، نويسنده , , Christoph and Chen، نويسنده , , Jessie and Patrick، نويسنده , , Brian O. and Polishchuk، نويسنده , , Elena and Orvig، نويسنده , , Chris، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
8
From page
276
To page
283
Abstract
The syntheses and characterization of new multifunctional aminoquinoline-carboxamides and their ferrocene derivatives are reported, as well as their cytotoxicity against human colon adenocarcinoma (Caco-2, HTB-37), human breast carcinoma (HTB-129) and a normal cell line as a control (human normal breast epithelial cells MCF-10A, CRL-10317). All tested compounds showed higher activity against HTB-129 cells than against Caco-2 cells. The ferrocenyl-chloroquine amide conjugates displayed higher activity against both cancer cells than did their parent organic compounds.
Keywords
Aminoquinoline , Carboxamides , Ferrocenyl-chloroquine conjugates , cytotoxicity , Ferrocene
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2012
Journal title
INORGANICA CHIMICA ACTA
Record number
1331337
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