The synthesis and characterization of 4-isopropylanilino derivatives of cyclotriphosphazene

Hexachlorocyclotriphosphazene N3P3Cl6 and gem-disubstituted cyclotriphosphazene derivatives N3P3Cl4X2 (X = Ph, PhS, PhNH) were reacted with 4-isopropylaniline to give geminal tetra and hexa substituted compounds (1a–4a, 1b–4b). The compounds (1a–4a, 1b–4b) were separated by column chromatography on silica gel and analyzed by elemental analysis, mass spectrometry, and 31P and 1H NMR spectroscopies, and also crystal structures of 2a and 3b were determined by X-ray crystallography. Compounds were prepared to cover the normal ranges of C-, S- and N-substituents in cyclophosphazene (X = Cl, Ph, SPh, NHPh). Compounds (1a–4a, 1b–4b) were reported for the first time. We additionally investigated the effect of substituent (Cl, Ph, SPh, NHPh) on 31P NMR chemical shifts of neighboring phosphorus atoms.