The Renal Protective Effects of Corn Silk and Feijoa by using in situ Rat Renal System

Background: Corn silk (CS) is widely used in Iranian traditional medicine. Feijoa sellowiana (FS), on the other hand, is a non-native plant widespread in the southern part of Iran. The aim of the present study was to examine the renal protective activity of CS and FS against dosage-induced ecstasy (MDMA) by in situ rat renal perfusion (IRRP) system. Methods: Hydro-alcoholic extracts of CS and FS (10, 20, 40 and 100 mg/ kg) were studied for their renal protective activities by IRRP system. In this study, the kidneys were perfused with Kerbs-Henseleit buffer, containing different concentrations of hydro-alcoholic (HA) extracts of CS and FS (10, 20, 40, 50, and 100mg/kg) added to the buffer and perfused for two hours. During the perfusion, many factors, including urea, creatinine and GSH levels assessed as indicator of renal viability. Consequently, sections of renal tissue were examined for any histopathological changes. Results: The results showed that histopathological changes in renal tissue related to HA extract of CS AND FS concentrations dose-dependently. Doses of 50, 100 mg/kg caused significant histopathological changes (P < 0.05). Glutathione (GSH) levels of samples perfused by HA extract of CS and FS increased compared with the positive control group. Conclusion: Renal protective effects of CS and FS decrease lipid peroxidation, although other mechanisms may also be involved.