Initiation of angiogenic Kaposiʹs sarcoma lesions

A new mouse model reported in this issue of Cancer Cell implies that VEGF/KDR-mediated paracrine effects induced by the lytic cycle vGPCR signaling protein encoded by human Kaposiʹs sarcoma-associated herpesvirus (KSHV or HHV8) may be involved in promoting the proliferation of the KSHV latently infected spindle endothelial cells of Kaposiʹs sarcoma.