Author/Authors :
Wang، نويسنده , , Shunyou and Gao، نويسنده , , Jing and Lei، نويسنده , , Qunying and Rozengurt، نويسنده , , Nora and Pritchard، نويسنده , , Colin and Jiao، نويسنده , , Jing and Thomas، نويسنده , , George V. and Li، نويسنده , , Gang and Roy-Burman، نويسنده , , Pradip and Nelson، نويسنده , , Peter S. and Liu، نويسنده , , Xin and Wu، نويسنده , , Hong، نويسنده ,
Abstract :
The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those “signature” genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.
