Title of article
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas
Author/Authors
Chen، نويسنده , , Jindong and Lui، نويسنده , , Weng-Onn and Vos، نويسنده , , Michele D. and Clark، نويسنده , , Geoffrey J. and Takahashi، نويسنده , , Masayuki and Schoumans، نويسنده , , Jacqueline and Khoo، نويسنده , , Sok Kean and Petillo، نويسنده , , David and Lavery، نويسنده , , Todd and Sugimura، نويسنده , , Jun and Astuti، نويسنده , , Dewi and Zhang، نويسنده , , Chun and Kagawa، نويسنده , , Susumu and Maher، نويسنده , , Eamonn R. and Larsson، نويسنده , , Catharina and Alberts، نويسنده , , Arthur S. and Kanayama، نويسنده , , Hiro-omi and Teh، نويسنده , , Bin Tean Teh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
9
From page
405
To page
413
Abstract
By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.
Journal title
Cancer Cell
Serial Year
2003
Journal title
Cancer Cell
Record number
1335309
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